Drug interactions
Crisantaspase + Vincristine
Severity: Moderate
Crisantaspase and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asparaginase given with or just before vincristine may increase vincristine toxicity, particularly neurotoxicity. The effect is attributed to reduced hepatic clearance of vincristine.
What this interaction means in plain words
Crisantaspase and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crisantaspase belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Asparaginase-related hepatic impairment may reduce vincristine clearance.
What to do
Give vincristine at least 12 to 24 hours before asparaginase where the protocol allows. Monitor for peripheral neuropathy, constipation and ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crisantaspase
- Crisantaspase + Cytarabine Moderate
- Crisantaspase + Methotrexate Moderate
- Crisantaspase + Prednisone Moderate
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Crisantaspase with Vincristine?
MediHelp rates the interaction as moderate. Crisantaspase and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asparaginase given with or just before vincristine may increase vincristine toxicity, particularly neurotoxicity. The effect is attributed to reduced hepatic clearance of vincristine.
How serious is the interaction between Crisantaspase and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give vincristine at least 12 to 24 hours before asparaginase where the protocol allows. Monitor for peripheral neuropathy, constipation and ileus.
What other medicines interact with Crisantaspase?
MediHelp also lists interactions of Crisantaspase with, for example, Cytarabine, Methotrexate, Prednisone. The full list is on the Crisantaspase page.
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