Drug interactions
Crisantaspase + Prednisone
Severity: Moderate
Crisantaspase and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids given with or shortly before asparaginase may further alter coagulation parameters, including lower fibrinogen and antithrombin III. This may increase the risk of thrombosis or bleeding.
What this interaction means in plain words
Crisantaspase and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crisantaspase belongs to Oncology; Prednisone belongs to Endocrine.
Why it happens
Additive effects on hepatic synthesis of coagulation proteins, with asparaginase reducing fibrinogen and antithrombin.
What to do
Monitor fibrinogen, antithrombin III and coagulation tests during therapy. Replace factors or consider thromboprophylaxis based on clinical risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crisantaspase
- Crisantaspase + Cytarabine Moderate
- Crisantaspase + Methotrexate Moderate
- Crisantaspase + Vincristine Moderate
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Crisantaspase with Prednisone?
MediHelp rates the interaction as moderate. Crisantaspase and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids given with or shortly before asparaginase may further alter coagulation parameters, including lower fibrinogen and antithrombin III. This may increase the risk of thrombosis or bleeding.
How serious is the interaction between Crisantaspase and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fibrinogen, antithrombin III and coagulation tests during therapy. Replace factors or consider thromboprophylaxis based on clinical risk.
What other medicines interact with Crisantaspase?
MediHelp also lists interactions of Crisantaspase with, for example, Cytarabine, Methotrexate, Vincristine. The full list is on the Crisantaspase page.
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