Drug interactions
Cyanocobalamin + Glipizide-metformin
Severity: Minor
Cyanocobalamin and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin use lowers serum vitamin B12 and can lead to deficiency, with possible anemia or neuropathy. Cyanocobalamin is the replacement that corrects this, so the pairing is therapeutic rather than harmful.
What this interaction means in plain words
Cyanocobalamin and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Glipizide-metformin belongs to Endocrine.
Why it happens
Metformin impairs calcium-dependent ileal absorption of the vitamin B12-intrinsic factor complex.
What to do
Check vitamin B12 periodically in patients on long-term metformin, particularly those with anemia or neuropathy, and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Glipizide-metformin?
MediHelp rates the interaction as minor. Cyanocobalamin and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin use lowers serum vitamin B12 and can lead to deficiency, with possible anemia or neuropathy. Cyanocobalamin is the replacement that corrects this, so the pairing is therapeutic rather than harmful.
How serious is the interaction between Cyanocobalamin and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check vitamin B12 periodically in patients on long-term metformin, particularly those with anemia or neuropathy, and supplement if low.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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