Drug interactions
Cyanocobalamin + Glyburide-metformin
Severity: Minor
Cyanocobalamin and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin therapy can lower vitamin B12 levels and occasionally cause deficiency, with anemia or neuropathy. Cyanocobalamin supplementation can correct or prevent this.
What this interaction means in plain words
Cyanocobalamin and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
Why it happens
Metformin interferes with calcium-dependent absorption of the vitamin B12-intrinsic factor complex in the ileum.
What to do
Check vitamin B12 periodically in long-term metformin users, especially with anemia or neuropathy, and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Glyburide-metformin?
MediHelp rates the interaction as minor. Cyanocobalamin and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin therapy can lower vitamin B12 levels and occasionally cause deficiency, with anemia or neuropathy. Cyanocobalamin supplementation can correct or prevent this.
How serious is the interaction between Cyanocobalamin and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check vitamin B12 periodically in long-term metformin users, especially with anemia or neuropathy, and supplement if low.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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