Drug interactions
Cyanocobalamin + Metformin-pioglitazone
Severity: Minor
Cyanocobalamin and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin use can reduce vitamin B12 absorption and lead to low serum B12 levels or deficiency in some patients. Cyanocobalamin is the supplement used to correct this, so it is not harmful but reflects the effect of metformin.
What this interaction means in plain words
Cyanocobalamin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Metformin impairs calcium-dependent ileal absorption of the vitamin B12-intrinsic factor complex.
What to do
Check vitamin B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Cyanocobalamin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin use can reduce vitamin B12 absorption and lead to low serum B12 levels or deficiency in some patients. Cyanocobalamin is the supplement used to correct this, so it is not harmful but reflects the effect of metformin.
How serious is the interaction between Cyanocobalamin and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check vitamin B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if deficient.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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