Drug interactions
Cyanocobalamin + Metformin-repaglinide
Severity: Minor
Cyanocobalamin and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin use is associated with reduced vitamin B12 absorption and lower serum B12 levels, which can eventually lead to deficiency and neuropathy or anemia. Cyanocobalamin supplementation can correct this effect rather than being harmed by it.
What this interaction means in plain words
Cyanocobalamin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Metformin impairs calcium-dependent ileal absorption of the vitamin B12-intrinsic factor complex.
What to do
Check vitamin B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyanocobalamin and Metformin-repaglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-repaglinide
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Metformin-repaglinide?
MediHelp rates the interaction as minor. Cyanocobalamin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin use is associated with reduced vitamin B12 absorption and lower serum B12 levels, which can eventually lead to deficiency and neuropathy or anemia. Cyanocobalamin supplementation can correct this effect rather than being harmed by it.
How serious is the interaction between Cyanocobalamin and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check vitamin B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if deficient.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
