Drug interactions
Cyanocobalamin + Pantoprazole
Severity: Minor
Cyanocobalamin and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gastric acid is needed to release vitamin B12 from dietary protein, so long-term pantoprazole can reduce absorption of food-bound B12. Crystalline cyanocobalamin supplements are less affected. Prolonged use may contribute to B12 deficiency.
What this interaction means in plain words
Cyanocobalamin and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Acid suppression impairs release of protein-bound vitamin B12 for absorption.
What to do
Monitor B12 status in long-term pantoprazole users, especially older or at-risk patients, and supplement if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyanocobalamin
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Cyanocobalamin with Pantoprazole?
MediHelp rates the interaction as minor. Cyanocobalamin and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gastric acid is needed to release vitamin B12 from dietary protein, so long-term pantoprazole can reduce absorption of food-bound B12. Crystalline cyanocobalamin supplements are less affected. Prolonged use may contribute to B12 deficiency.
How serious is the interaction between Cyanocobalamin and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 status in long-term pantoprazole users, especially older or at-risk patients, and supplement if levels are low.
What other medicines interact with Cyanocobalamin?
MediHelp also lists interactions of Cyanocobalamin with, for example, Chloramphenicol, Dichlorphenamide, Metformin. The full list is on the Cyanocobalamin page.
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