Drug interactions
Cyanocobalamin + Streptomycin
Severity: Minor
Cyanocobalamin and Streptomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides given orally, such as neomycin, can impair vitamin B12 absorption, but parenteral streptomycin has no meaningful effect on it. The interaction as described is not supported for the usual systemic use of streptomycin.
What this interaction means in plain words
Cyanocobalamin and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Streptomycin belongs to Anti Bacterial.
Why it happens
Possible mucosal effects reducing B12 absorption with oral aminoglycosides; not established for streptomycin.
What to do
No specific action is needed. Monitor B12 status only if prolonged oral aminoglycoside exposure and malabsorption are suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyanocobalamin and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Streptomycin
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Streptomycin?
MediHelp rates the interaction as minor. Cyanocobalamin and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminoglycosides given orally, such as neomycin, can impair vitamin B12 absorption, but parenteral streptomycin has no meaningful effect on it. The interaction as described is not supported for the usual systemic use of streptomycin.
How serious is the interaction between Cyanocobalamin and Streptomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Monitor B12 status only if prolonged oral aminoglycoside exposure and malabsorption are suspected.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
