Drug interactions
Cyanocobalamin + Tobramycin
Severity: Minor
Cyanocobalamin and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aminoglycosides can cause malabsorption and reduce intestinal uptake of vitamin B12. This is of limited significance with short courses.
What this interaction means in plain words
Cyanocobalamin and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Tobramycin belongs to Anti Bacterial.
Why it happens
Aminoglycosides can damage intestinal mucosa and impair B12 absorption in the gut.
What to do
No routine action for short courses; monitor B12 status if oral aminoglycoside is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Tobramycin?
MediHelp rates the interaction as minor. Cyanocobalamin and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral aminoglycosides can cause malabsorption and reduce intestinal uptake of vitamin B12. This is of limited significance with short courses.
How serious is the interaction between Cyanocobalamin and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action for short courses; monitor B12 status if oral aminoglycoside is used long term.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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