Drug interactions
Cyclizine + Diamorphine
Severity: Moderate
Cyclizine and Diamorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is commonly given with diamorphine to treat opioid-induced nausea, but the pair increases sedation and may add to respiratory depression. Cyclizine anticholinergic effects may also worsen constipation and urinary retention.
What this interaction means in plain words
Cyclizine and Diamorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive anticholinergic effects on gut and bladder.
What to do
Monitor sedation level and respiratory rate, particularly after dose increases. Review for constipation and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Diamorphine?
MediHelp rates the interaction as moderate. Cyclizine and Diamorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is commonly given with diamorphine to treat opioid-induced nausea, but the pair increases sedation and may add to respiratory depression. Cyclizine anticholinergic effects may also worsen constipation and urinary retention.
How serious is the interaction between Cyclizine and Diamorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, particularly after dose increases. Review for constipation and urinary retention.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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