Drug interactions
Cyclizine + Difenoxin
Severity: Moderate
Cyclizine and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal metabolite of diphenoxylate and can cause drowsiness. With cyclizine, sedation is increased, and additive anticholinergic effects may promote ileus or urinary retention.
What this interaction means in plain words
Cyclizine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Monitor for excessive drowsiness and abdominal distension, and counsel on avoiding driving. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Difenoxin
Frequently asked questions
Can I take Cyclizine with Difenoxin?
MediHelp rates the interaction as moderate. Cyclizine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal metabolite of diphenoxylate and can cause drowsiness. With cyclizine, sedation is increased, and additive anticholinergic effects may promote ileus or urinary retention.
How serious is the interaction between Cyclizine and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and abdominal distension, and counsel on avoiding driving. Use the lowest effective doses.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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