Drug interactions
Cyclizine + Droperidol
Severity: Moderate
Cyclizine and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and droperidol can prolong the QT interval, which matters in patients with other risk factors. Cyclizine also has dopamine-related and anticholinergic actions that may add to extrapyramidal or antimuscarinic effects.
What this interaction means in plain words
Cyclizine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects, with droperidol-related QT prolongation as an added risk.
What to do
Monitor sedation, and obtain an ECG with electrolyte correction in patients with QT risk factors. Avoid stacking multiple antiemetics where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Droperidol?
MediHelp rates the interaction as moderate. Cyclizine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and droperidol can prolong the QT interval, which matters in patients with other risk factors. Cyclizine also has dopamine-related and anticholinergic actions that may add to extrapyramidal or antimuscarinic effects.
How serious is the interaction between Cyclizine and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, and obtain an ECG with electrolyte correction in patients with QT risk factors. Avoid stacking multiple antiemetics where possible.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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