Drug interactions
Cyclizine + Epinephrine
Severity: Minor
Cyclizine and Epinephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine's stimulant effects might slightly oppose cyclizine drowsiness, but no clinically important interaction is established. Cyclizine can cause mild tachycardia, which could theoretically add to epinephrine's cardiac effects.
What this interaction means in plain words
Cyclizine and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclizine belongs to Respiratory; Epinephrine belongs to Endocrine.
Why it happens
Opposing CNS effects with possible minor additive heart rate effects (anticholinergic plus adrenergic); no established pharmacokinetic interaction.
What to do
No dose adjustment is needed. Monitor heart rate and blood pressure when epinephrine is given to patients on cyclizine, particularly those with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Cyclizine with Epinephrine?
MediHelp rates the interaction as minor. Cyclizine and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine's stimulant effects might slightly oppose cyclizine drowsiness, but no clinically important interaction is established. Cyclizine can cause mild tachycardia, which could theoretically add to epinephrine's cardiac effects.
How serious is the interaction between Cyclizine and Epinephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor heart rate and blood pressure when epinephrine is given to patients on cyclizine, particularly those with cardiac disease.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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