Drug interactions
Cyclizine + Ethanol
Severity: Moderate
Cyclizine and Ethanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol enhances the sedative effect of cyclizine and worsens impairment of alertness, coordination and driving ability. At high intakes, respiratory depression is possible.
What this interaction means in plain words
Cyclizine and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from alcohol and central H1 antagonism.
What to do
Advise patients to avoid alcohol while taking cyclizine and not to drive or operate machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Ethanol?
MediHelp rates the interaction as moderate. Cyclizine and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol enhances the sedative effect of cyclizine and worsens impairment of alertness, coordination and driving ability. At high intakes, respiratory depression is possible.
How serious is the interaction between Cyclizine and Ethanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol while taking cyclizine and not to drive or operate machinery.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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