Drug interactions
Cyclizine + Hyoscyamine spray
Severity: Moderate
Cyclizine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral or sublingual hyoscyamine spray is absorbed systemically and adds to the antimuscarinic effects of cyclizine. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Cyclizine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects and reduce the dose or stop one agent if they develop. Use particular caution in older adults and in patients with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Cyclizine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral or sublingual hyoscyamine spray is absorbed systemically and adds to the antimuscarinic effects of cyclizine. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion.
How serious is the interaction between Cyclizine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce the dose or stop one agent if they develop. Use particular caution in older adults and in patients with glaucoma or urinary obstruction.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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