Drug interactions
Cyclizine + Kava
Severity: Moderate
Cyclizine and Kava: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Kava has sedative and anxiolytic effects and may add to the drowsiness from cyclizine, impairing alertness and coordination. Kava has also been linked to hepatotoxicity, which adds a separate concern.
What this interaction means in plain words
Cyclizine and Kava can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from kavalactones and a sedating antihistamine.
What to do
Advise avoiding kava while using cyclizine and counsel against driving or operating machinery. Use an alternative if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Kava?
MediHelp rates the interaction as moderate. Cyclizine and Kava can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Kava has sedative and anxiolytic effects and may add to the drowsiness from cyclizine, impairing alertness and coordination. Kava has also been linked to hepatotoxicity, which adds a separate concern.
How serious is the interaction between Cyclizine and Kava?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding kava while using cyclizine and counsel against driving or operating machinery. Use an alternative if sedation is troublesome.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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