Drug interactions
Cyclizine + Ketamine
Severity: Moderate
Cyclizine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine antiemetic with anticholinergic effects. With ketamine, it may increase sedation and cognitive impairment, and anticholinergic effects may add to tachycardia.
What this interaction means in plain words
Cyclizine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and NMDA antagonism.
What to do
Monitor sedation and heart rate, and use the lowest effective doses of each drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Ketamine?
MediHelp rates the interaction as moderate. Cyclizine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine antiemetic with anticholinergic effects. With ketamine, it may increase sedation and cognitive impairment, and anticholinergic effects may add to tachycardia.
How serious is the interaction between Cyclizine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and heart rate, and use the lowest effective doses of each drug.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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