Drug interactions
Cyclizine + Loprazolam
Severity: Moderate
Cyclizine and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so together they increase drowsiness, dizziness and psychomotor impairment. Falls and next-day impairment are particular concerns.
What this interaction means in plain words
Cyclizine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via histamine H1 blockade and enhanced GABA-A activity.
What to do
Use the lowest effective doses and warn the patient about driving and operating machinery. Avoid in older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclizine and Loprazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Loprazolam?
MediHelp rates the interaction as moderate. Cyclizine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so together they increase drowsiness, dizziness and psychomotor impairment. Falls and next-day impairment are particular concerns.
How serious is the interaction between Cyclizine and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn the patient about driving and operating machinery. Avoid in older adults where possible.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
