Drug interactions
Cyclizine + Meclizine
Severity: Moderate
Cyclizine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine and meclizine are both piperazine-class antihistamines with antiemetic use, sedative effects and anticholinergic activity. Combining them is therapeutically duplicative and increases drowsiness and anticholinergic adverse effects.
What this interaction means in plain words
Cyclizine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Meclizine belongs to Respiratory.
Why it happens
Additive H1-receptor and muscarinic receptor antagonism from two drugs of the same class.
What to do
Avoid concurrent use and choose a single agent for nausea or vertigo. If both have been taken, monitor for sedation, urinary retention and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Meclizine
Frequently asked questions
Can I take Cyclizine with Meclizine?
MediHelp rates the interaction as moderate. Cyclizine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine and meclizine are both piperazine-class antihistamines with antiemetic use, sedative effects and anticholinergic activity. Combining them is therapeutically duplicative and increases drowsiness and anticholinergic adverse effects.
How serious is the interaction between Cyclizine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single agent for nausea or vertigo. If both have been taken, monitor for sedation, urinary retention and confusion.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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