Drug interactions
Cyclizine + Orphenadrine
Severity: Moderate
Cyclizine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity and cause sedation, so combined use can intensify dry mouth, blurred vision, urinary retention, constipation, confusion and drowsiness. Older adults and patients with glaucoma, prostatic enlargement or cognitive impairment are at particular risk.
What this interaction means in plain words
Cyclizine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade and additive central histamine H1 and CNS depressant effects.
What to do
Monitor for anticholinergic toxicity and excessive sedation, and warn the patient against driving. Reduce doses or choose a non-anticholinergic alternative in elderly or susceptible patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Orphenadrine?
MediHelp rates the interaction as moderate. Cyclizine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity and cause sedation, so combined use can intensify dry mouth, blurred vision, urinary retention, constipation, confusion and drowsiness. Older adults and patients with glaucoma, prostatic enlargement or cognitive impairment are at particular risk.
How serious is the interaction between Cyclizine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and excessive sedation, and warn the patient against driving. Reduce doses or choose a non-anticholinergic alternative in elderly or susceptible patients.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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