Drug interactions
Cyclizine + Oxybutynin transdermal
Severity: Moderate
Cyclizine and Oxybutynin transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic properties and transdermal oxybutynin delivers a systemically absorbed antimuscarinic. Together they can add to dry mouth, constipation, urinary retention, blurred vision and confusion, especially in older patients.
What this interaction means in plain words
Cyclizine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antagonism at muscarinic receptors.
What to do
Monitor for anticholinergic adverse effects, particularly urinary retention and cognitive changes in the elderly. Consider a non-anticholinergic antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Oxybutynin transdermal?
MediHelp rates the interaction as moderate. Cyclizine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has anticholinergic properties and transdermal oxybutynin delivers a systemically absorbed antimuscarinic. Together they can add to dry mouth, constipation, urinary retention, blurred vision and confusion, especially in older patients.
How serious is the interaction between Cyclizine and Oxybutynin transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly urinary retention and cognitive changes in the elderly. Consider a non-anticholinergic antiemetic if symptoms develop.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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