Drug interactions
Cyclizine + Papaveretum
Severity: Moderate
Cyclizine and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opioid mixture and cyclizine is a sedating antihistamine, so together they increase drowsiness and may deepen CNS and respiratory depression. Cyclizine is commonly co-prescribed with opioids as an antiemetic, so the combination is often intentional but needs awareness.
What this interaction means in plain words
Cyclizine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and histamine H1 blockade with anticholinergic action.
What to do
Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation and in elderly patients. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Papaveretum?
MediHelp rates the interaction as moderate. Cyclizine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum is an opioid mixture and cyclizine is a sedating antihistamine, so together they increase drowsiness and may deepen CNS and respiratory depression. Cyclizine is commonly co-prescribed with opioids as an antiemetic, so the combination is often intentional but needs awareness.
How serious is the interaction between Cyclizine and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation and in elderly patients. Counsel patients to avoid driving and alcohol.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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