Drug interactions
Cyclizine + Passion flower
Severity: Moderate
Cyclizine and Passion flower: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passion flower has sedative properties attributed to its GABAergic activity and may add to the drowsiness caused by cyclizine. The result can be impaired alertness and psychomotor performance.
What this interaction means in plain words
Cyclizine and Passion flower can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; the herb's sedative effect is thought to involve GABAergic activity, though the evidence is limited.
What to do
Advise patients to avoid combining them when driving or operating machinery. Monitor for excessive sedation and stop the herbal product if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Passion flower?
MediHelp rates the interaction as moderate. Cyclizine and Passion flower can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passion flower has sedative properties attributed to its GABAergic activity and may add to the drowsiness caused by cyclizine. The result can be impaired alertness and psychomotor performance.
How serious is the interaction between Cyclizine and Passion flower?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid combining them when driving or operating machinery. Monitor for excessive sedation and stop the herbal product if it occurs.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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