Drug interactions
Cyclizine + Phendimetrazine
Severity: Minor
Cyclizine and Phendimetrazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic stimulant anorectic whereas cyclizine is sedating and anticholinergic. The effects are partly opposing and unpredictable, and the combination may add tachycardia or raise heart rate through the anticholinergic effect.
What this interaction means in plain words
Cyclizine and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects and possible additive tachycardia; no well-defined interaction mechanism.
What to do
No routine adjustment is needed; monitor heart rate and blood pressure and the patient's response to each drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Phendimetrazine?
MediHelp rates the interaction as minor. Cyclizine and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phendimetrazine is a sympathomimetic stimulant anorectic whereas cyclizine is sedating and anticholinergic. The effects are partly opposing and unpredictable, and the combination may add tachycardia or raise heart rate through the anticholinergic effect.
How serious is the interaction between Cyclizine and Phendimetrazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor heart rate and blood pressure and the patient's response to each drug.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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