Drug interactions
Cyclizine + Pimozide
Severity: Moderate
Cyclizine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic effects, and with pimozide it can cause additive drowsiness, dry mouth, constipation and urinary retention. Both agents have been linked to QT effects to differing degrees, which adds to the concern in susceptible patients.
What this interaction means in plain words
Cyclizine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from combined H1 and dopamine receptor blockade.
What to do
Monitor for sedation and anticholinergic effects, and consider an ECG in patients with other QT risk factors. Choose an alternative antiemetic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclizine and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Pimozide?
MediHelp rates the interaction as moderate. Cyclizine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic effects, and with pimozide it can cause additive drowsiness, dry mouth, constipation and urinary retention. Both agents have been linked to QT effects to differing degrees, which adds to the concern in susceptible patients.
How serious is the interaction between Cyclizine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, and consider an ECG in patients with other QT risk factors. Choose an alternative antiemetic if possible.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
