Drug interactions
Cyclizine + Propantheline
Severity: Moderate
Cyclizine and Propantheline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antimuscarinic, so their combination can magnify dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Elderly patients and those with glaucoma or bladder outlet obstruction are most vulnerable.
What this interaction means in plain words
Cyclizine and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects and consider a non-anticholinergic antiemetic. Avoid in patients with narrow-angle glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Propantheline?
MediHelp rates the interaction as moderate. Cyclizine and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antimuscarinic, so their combination can magnify dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Elderly patients and those with glaucoma or bladder outlet obstruction are most vulnerable.
How serious is the interaction between Cyclizine and Propantheline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and consider a non-anticholinergic antiemetic. Avoid in patients with narrow-angle glaucoma or urinary retention.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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