Drug interactions
Cyclizine + Protriptyline
Severity: Moderate
Cyclizine and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant with antimuscarinic effects, and cyclizine adds further anticholinergic and sedative activity. Combined use raises the risk of urinary retention, constipation, confusion, tachycardia and drowsiness.
What this interaction means in plain words
Cyclizine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic blockade and additive sedation from histamine H1 antagonism.
What to do
Monitor for anticholinergic toxicity and sedation, especially in elderly patients, and reduce doses or select another antiemetic if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Protriptyline?
MediHelp rates the interaction as moderate. Cyclizine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant with antimuscarinic effects, and cyclizine adds further anticholinergic and sedative activity. Combined use raises the risk of urinary retention, constipation, confusion, tachycardia and drowsiness.
How serious is the interaction between Cyclizine and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, especially in elderly patients, and reduce doses or select another antiemetic if effects emerge.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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