Drug interactions
Cyclizine + Pyridostigmine
Severity: Moderate
Cyclizine and Pyridostigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic activity that can oppose the cholinergic effect of pyridostigmine. In myasthenia gravis this may reduce symptom control, although the clinical effect is usually modest.
What this interaction means in plain words
Cyclizine and Pyridostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Pyridostigmine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between muscarinic blockade and cholinesterase inhibition.
What to do
Monitor myasthenic symptoms and muscarinic effects, and adjust the pyridostigmine dose if needed. Prefer a non-anticholinergic antiemetic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pyridostigmine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Pyridostigmine?
MediHelp rates the interaction as moderate. Cyclizine and Pyridostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has anticholinergic activity that can oppose the cholinergic effect of pyridostigmine. In myasthenia gravis this may reduce symptom control, although the clinical effect is usually modest.
How serious is the interaction between Cyclizine and Pyridostigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor myasthenic symptoms and muscarinic effects, and adjust the pyridostigmine dose if needed. Prefer a non-anticholinergic antiemetic where possible.
What other medicines interact with Pyridostigmine?
MediHelp also lists interactions of Pyridostigmine with, for example, Echothiophate iodide, Huperzine a, Neostigmine. The full list is on the Pyridostigmine page.
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