Drug interactions
Cyclizine + Secretin
Severity: Moderate
Cyclizine and Secretin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic properties that can blunt the pancreatic response to secretin. A stimulation test may therefore be falsely hyporesponsive and misleading.
What this interaction means in plain words
Cyclizine and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticholinergic inhibition of pancreatic secretory response, antagonising secretin stimulation.
What to do
Stop cyclizine for several half-lives before secretin testing, and interpret results cautiously if it cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Secretin?
MediHelp rates the interaction as moderate. Cyclizine and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has anticholinergic properties that can blunt the pancreatic response to secretin. A stimulation test may therefore be falsely hyporesponsive and misleading.
How serious is the interaction between Cyclizine and Secretin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop cyclizine for several half-lives before secretin testing, and interpret results cautiously if it cannot be stopped.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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