Drug interactions
Cyclizine + Triazolam
Severity: Moderate
Cyclizine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine and triazolam is a short-acting benzodiazepine hypnotic. Taken together they can produce greater drowsiness, slowed reaction time and impaired psychomotor performance than either drug alone, which raises the risk of falls and accidents.
What this interaction means in plain words
Cyclizine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from histamine H1 blockade and GABA-A receptor potentiation.
What to do
Use the lowest effective doses and warn the patient to avoid driving and alcohol. Take extra care in elderly patients because of fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Triazolam?
MediHelp rates the interaction as moderate. Cyclizine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine and triazolam is a short-acting benzodiazepine hypnotic. Taken together they can produce greater drowsiness, slowed reaction time and impaired psychomotor performance than either drug alone, which raises the risk of falls and accidents.
How serious is the interaction between Cyclizine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn the patient to avoid driving and alcohol. Take extra care in elderly patients because of fall risk.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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