Drug interactions
Cyclizine + Trifluoperazine
Severity: Moderate
Cyclizine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so together they can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion. Cyclizine's antiemetic effect may also mask early signs of adverse effects of the phenothiazine.
What this interaction means in plain words
Cyclizine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive H1 antihistaminic, antimuscarinic and CNS depressant effects; the claimed absorption effect is not well established.
What to do
Monitor for oversedation and anticholinergic effects, particularly in elderly patients. Reduce the dose of one agent or choose a less anticholinergic antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclizine and Trifluoperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Trifluoperazine?
MediHelp rates the interaction as moderate. Cyclizine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so together they can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion. Cyclizine's antiemetic effect may also mask early signs of adverse effects of the phenothiazine.
How serious is the interaction between Cyclizine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, particularly in elderly patients. Reduce the dose of one agent or choose a less anticholinergic antiemetic if symptoms develop.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
