Drug interactions
Cyclizine + Yohimbine
Severity: Minor
Cyclizine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine causes sedation while yohimbine is a stimulant with anxiogenic and sympathomimetic effects, so their effects partly oppose each other. No consistent, clinically significant interaction is documented, and the net effect is unpredictable.
What this interaction means in plain words
Cyclizine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects: H1 blockade and sedation versus central alpha-2 antagonism and increased noradrenergic activity.
What to do
No specific action is required beyond awareness. Monitor the patient's response and be aware that yohimbine may cause anxiety or hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Yohimbine?
MediHelp rates the interaction as minor. Cyclizine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclizine causes sedation while yohimbine is a stimulant with anxiogenic and sympathomimetic effects, so their effects partly oppose each other. No consistent, clinically significant interaction is documented, and the net effect is unpredictable.
How serious is the interaction between Cyclizine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required beyond awareness. Monitor the patient's response and be aware that yohimbine may cause anxiety or hypertension.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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