Drug interactions
Cyclobenzaprine + Diazepam
Severity: Moderate
Cyclobenzaprine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is a tricyclic-related muscle relaxant that causes drowsiness, and together with diazepam sedation and psychomotor impairment are increased. Anticholinergic effects may add to confusion in older patients.
What this interaction means in plain words
Cyclobenzaprine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from antihistaminic and anticholinergic effects with GABA-A potentiation.
What to do
Use the lowest doses for the shortest time and monitor for sedation and falls. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Diazepam?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is a tricyclic-related muscle relaxant that causes drowsiness, and together with diazepam sedation and psychomotor impairment are increased. Anticholinergic effects may add to confusion in older patients.
How serious is the interaction between Cyclobenzaprine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest doses for the shortest time and monitor for sedation and falls. Advise against driving and alcohol.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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