Drug interactions
Cyclobenzaprine + Dimenhydrinate
Severity: Moderate
Cyclobenzaprine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine with anticholinergic activity, and cyclobenzaprine has similar properties. Together they can cause marked drowsiness, dry mouth, urinary retention and confusion, especially in older adults.
What this interaction means in plain words
Cyclobenzaprine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Warn patients about drowsiness and avoid driving; in older patients avoid the combination or use the lowest doses and watch for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Cyclobenzaprine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine with anticholinergic activity, and cyclobenzaprine has similar properties. Together they can cause marked drowsiness, dry mouth, urinary retention and confusion, especially in older adults.
How serious is the interaction between Cyclobenzaprine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and avoid driving; in older patients avoid the combination or use the lowest doses and watch for anticholinergic toxicity.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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