Drug interactions
Cyclobenzaprine + Diphenoxylate
Severity: Moderate
Cyclobenzaprine and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid with CNS-depressant activity at higher doses and has weak anticholinergic effects through its atropine component. With cyclobenzaprine, sedation and anticholinergic effects can be increased.
What this interaction means in plain words
Cyclobenzaprine and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for drowsiness, urinary retention and ileus, particularly in older adults. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Cyclobenzaprine with Diphenoxylate?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid with CNS-depressant activity at higher doses and has weak anticholinergic effects through its atropine component. With cyclobenzaprine, sedation and anticholinergic effects can be increased.
How serious is the interaction between Cyclobenzaprine and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, urinary retention and ileus, particularly in older adults. Use the lowest effective doses.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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