Drug interactions
Cyclobenzaprine + Doxylamine
Severity: Moderate
Cyclobenzaprine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine with anticholinergic effects, and taking it with cyclobenzaprine amplifies drowsiness and antimuscarinic adverse effects. Impaired alertness and confusion are more likely in older patients.
What this interaction means in plain words
Cyclobenzaprine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic activity.
What to do
Advise against driving or hazardous tasks and avoid the combination in older adults; reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Cyclobenzaprine with Doxylamine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine with anticholinergic effects, and taking it with cyclobenzaprine amplifies drowsiness and antimuscarinic adverse effects. Impaired alertness and confusion are more likely in older patients.
How serious is the interaction between Cyclobenzaprine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving or hazardous tasks and avoid the combination in older adults; reduce doses if oversedation occurs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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