Drug interactions
Cyclobenzaprine + Lorazepam
Severity: Moderate
Cyclobenzaprine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorazepam and cyclobenzaprine both depress the central nervous system, so combined use increases drowsiness, impaired coordination and risk of falls. Respiratory depression is possible at higher doses or with other depressants.
What this interaction means in plain words
Cyclobenzaprine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A enhancement and cyclobenzaprine's sedative actions.
What to do
Use the lowest effective doses for the shortest time, counsel against driving and alcohol, and monitor older patients closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Lorazepam
Frequently asked questions
Can I take Cyclobenzaprine with Lorazepam?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorazepam and cyclobenzaprine both depress the central nervous system, so combined use increases drowsiness, impaired coordination and risk of falls. Respiratory depression is possible at higher doses or with other depressants.
How serious is the interaction between Cyclobenzaprine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time, counsel against driving and alcohol, and monitor older patients closely.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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