Drug interactions
Cyclobenzaprine + Methadone
Severity: Moderate
Cyclobenzaprine and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating, so it adds to the CNS depression of methadone. It also has serotonergic and mild QT-prolonging potential, which adds to the concern.
What this interaction means in plain words
Cyclobenzaprine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with possible additive serotonergic and QT effects.
What to do
Use the lowest effective doses and advise avoiding driving. Monitor sedation and, in patients with cardiac risk factors, the ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Methadone?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating, so it adds to the CNS depression of methadone. It also has serotonergic and mild QT-prolonging potential, which adds to the concern.
How serious is the interaction between Cyclobenzaprine and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and advise avoiding driving. Monitor sedation and, in patients with cardiac risk factors, the ECG.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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