Drug interactions
Cyclobenzaprine + Oxybutynin
Severity: Moderate
Cyclobenzaprine and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and has notable anticholinergic and sedative effects. With oxybutynin it can cause additive dry mouth, constipation, urinary retention, drowsiness and confusion.
What this interaction means in plain words
Cyclobenzaprine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Oxybutynin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic and sedative effects, especially in older adults, and keep the cyclobenzaprine course short. Use an alternative muscle relaxant if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Oxybutynin?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and has notable anticholinergic and sedative effects. With oxybutynin it can cause additive dry mouth, constipation, urinary retention, drowsiness and confusion.
How serious is the interaction between Cyclobenzaprine and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic and sedative effects, especially in older adults, and keep the cyclobenzaprine course short. Use an alternative muscle relaxant if symptoms occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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