Drug interactions
Cyclobenzaprine + Rasagiline
Severity: Major
Cyclobenzaprine and Rasagiline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and has serotonergic activity, while rasagiline is an MAO-B inhibitor. Combined use has been associated with a risk of serotonin syndrome and hypertensive reactions. The cyclobenzaprine label contraindicates use with MAO inhibitors.
What this interaction means in plain words
Cyclobenzaprine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclobenzaprine belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Why it happens
Inhibition of monoamine oxidase combined with serotonin and norepinephrine reuptake effects raises monoaminergic activity.
What to do
Avoid the combination where possible and choose a different muscle relaxant. If used, watch for agitation, tremor, hyperthermia, clonus and blood pressure changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Rasagiline?
MediHelp rates the interaction as major. Cyclobenzaprine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclobenzaprine is structurally related to tricyclic antidepressants and has serotonergic activity, while rasagiline is an MAO-B inhibitor. Combined use has been associated with a risk of serotonin syndrome and hypertensive reactions. The cyclobenzaprine label contraindicates use with MAO inhibitors.
How serious is the interaction between Cyclobenzaprine and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a different muscle relaxant. If used, watch for agitation, tremor, hyperthermia, clonus and blood pressure changes.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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