Drug interactions
Cyclobenzaprine + Rocuronium
Severity: Minor
Cyclobenzaprine and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rocuronium is a nondepolarising neuromuscular blocker and cyclobenzaprine is a centrally acting muscle relaxant. Added effect on neuromuscular blockade is theoretical and likely small, but could prolong weakness.
What this interaction means in plain words
Cyclobenzaprine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclobenzaprine belongs to Musculoskeletal; Rocuronium belongs to Musculoskeletal.
Why it happens
Possible additive muscle relaxation; mostly theoretical.
What to do
Monitor neuromuscular blockade with train-of-four and titrate rocuronium accordingly. Confirm full recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Rocuronium
Frequently asked questions
Can I take Cyclobenzaprine with Rocuronium?
MediHelp rates the interaction as minor. Cyclobenzaprine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rocuronium is a nondepolarising neuromuscular blocker and cyclobenzaprine is a centrally acting muscle relaxant. Added effect on neuromuscular blockade is theoretical and likely small, but could prolong weakness.
How serious is the interaction between Cyclobenzaprine and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four and titrate rocuronium accordingly. Confirm full recovery before extubation.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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