Drug interactions
Cyclobenzaprine + Scopolamine
Severity: Moderate
Cyclobenzaprine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and has significant anticholinergic and sedative effects. Combined with scopolamine it can cause additive dry mouth, constipation, urinary retention, confusion and drowsiness.
What this interaction means in plain words
Cyclobenzaprine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and CNS depression.
What to do
Monitor for anticholinergic toxicity and sedation, and use the lowest effective doses. Avoid in older adults or those with urinary retention or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Scopolamine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and has significant anticholinergic and sedative effects. Combined with scopolamine it can cause additive dry mouth, constipation, urinary retention, confusion and drowsiness.
How serious is the interaction between Cyclobenzaprine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and use the lowest effective doses. Avoid in older adults or those with urinary retention or narrow-angle glaucoma.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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