Drug interactions
Cyclopenthiazide + Diclofenac
Severity: Moderate
Cyclopenthiazide and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of thiazide diuretics through sodium and water retention. Combined use may also increase the risk of renal impairment, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Cyclopenthiazide and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing thiazide action.
What to do
Monitor blood pressure, fluid status, renal function and electrolytes when starting or stopping the NSAID. Ensure adequate hydration and use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Cyclopenthiazide with Diclofenac?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effect of thiazide diuretics through sodium and water retention. Combined use may also increase the risk of renal impairment, particularly in volume-depleted or elderly patients.
How serious is the interaction between Cyclopenthiazide and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, renal function and electrolytes when starting or stopping the NSAID. Ensure adequate hydration and use the lowest effective NSAID dose.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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