Drug interactions
Cyclopenthiazide + Diflunisal
Severity: Moderate
Cyclopenthiazide and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may blunt the diuretic and blood pressure lowering effect of thiazide diuretics and increase the risk of renal impairment in dehydrated patients. Potassium changes are inconsistent.
What this interaction means in plain words
Cyclopenthiazide and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, opposing thiazide action.
What to do
Monitor blood pressure, renal function, fluid status and serum potassium. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Cyclopenthiazide with Diflunisal?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may blunt the diuretic and blood pressure lowering effect of thiazide diuretics and increase the risk of renal impairment in dehydrated patients. Potassium changes are inconsistent.
How serious is the interaction between Cyclopenthiazide and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function, fluid status and serum potassium. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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