Drug interactions
Cyclopenthiazide + Enalapril-hydrochlorothiazide
Severity: Moderate
Cyclopenthiazide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide is another thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This raises the risk of hypokalemia, hyponatremia, volume depletion and hypotension without meaningful extra benefit.
What this interaction means in plain words
Cyclopenthiazide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of distal tubular sodium chloride reabsorption with increased urinary potassium loss.
What to do
Avoid using two thiazides together. If unavoidable, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Cyclopenthiazide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide is another thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This raises the risk of hypokalemia, hyponatremia, volume depletion and hypotension without meaningful extra benefit.
How serious is the interaction between Cyclopenthiazide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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