Drug interactions
Cyclopenthiazide + Hydrochlorothiazide-losartan
Severity: Moderate
Cyclopenthiazide and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide is a second thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and dehydration. Losartan may offset potassium loss only partly.
What this interaction means in plain words
Cyclopenthiazide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate inhibition of the distal tubule sodium-chloride cotransporter, producing additive electrolyte and volume loss.
What to do
Avoid using two thiazides together; if combined, monitor sodium, potassium and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Cyclopenthiazide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide is a second thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and dehydration. Losartan may offset potassium loss only partly.
How serious is the interaction between Cyclopenthiazide and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together; if combined, monitor sodium, potassium and renal function closely.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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