Drug interactions
Cyclopenthiazide + Irbesartan
Severity: Minor
Cyclopenthiazide and Irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide, a thiazide diuretic, adds to the blood pressure lowering of irbesartan and offsets its potassium-raising tendency. Hypotension or renal function changes may occur at initiation, especially with volume depletion.
What this interaction means in plain words
Cyclopenthiazide and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects, with opposing effects on potassium.
What to do
Monitor blood pressure, electrolytes and creatinine after starting or changing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Cyclopenthiazide with Irbesartan?
MediHelp rates the interaction as minor. Cyclopenthiazide and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclopenthiazide, a thiazide diuretic, adds to the blood pressure lowering of irbesartan and offsets its potassium-raising tendency. Hypotension or renal function changes may occur at initiation, especially with volume depletion.
How serious is the interaction between Cyclopenthiazide and Irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and creatinine after starting or changing doses.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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