Drug interactions
Cyclopenthiazide + Methoxsalen
Severity: Moderate
Cyclopenthiazide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide, like other thiazides, can cause photosensitivity, and methoxsalen strongly increases UVA sensitivity. Together they may raise the risk of phototoxic burns.
What this interaction means in plain words
Cyclopenthiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects.
What to do
Counsel on photoprotection and monitor skin during phototherapy. Consider an alternative diuretic if phototoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Cyclopenthiazide with Methoxsalen?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide, like other thiazides, can cause photosensitivity, and methoxsalen strongly increases UVA sensitivity. Together they may raise the risk of phototoxic burns.
How serious is the interaction between Cyclopenthiazide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on photoprotection and monitor skin during phototherapy. Consider an alternative diuretic if phototoxicity develops.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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