Drug interactions
Cyclopenthiazide + Sulindac
Severity: Moderate
Cyclopenthiazide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as sulindac can reduce the antihypertensive and diuretic effects of thiazides and raise the risk of renal impairment in volume-depleted patients. The potassium effects are not reliably offsetting.
What this interaction means in plain words
Cyclopenthiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, antagonising thiazide effects.
What to do
Monitor blood pressure, renal function and electrolytes when starting or stopping the NSAID. Maintain hydration and use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Cyclopenthiazide with Sulindac?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as sulindac can reduce the antihypertensive and diuretic effects of thiazides and raise the risk of renal impairment in volume-depleted patients. The potassium effects are not reliably offsetting.
How serious is the interaction between Cyclopenthiazide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes when starting or stopping the NSAID. Maintain hydration and use the lowest effective NSAID dose.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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