Drug interactions
Cyclophosphamide + Cyclosporin
Severity: Moderate
Cyclophosphamide and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reports suggest cyclosporine levels may change with cyclophosphamide, and the combination increases immunosuppression and infection risk. Cyclophosphamide is a prodrug activated by CYP enzymes, and cyclosporine may alter its activation.
What this interaction means in plain words
Cyclophosphamide and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Possible CYP-mediated effects on cyclosporine and cyclophosphamide activation, plus additive immunosuppression; the kinetic effect is not well established.
What to do
Monitor cyclosporine trough levels, blood counts and renal function. Watch for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Cyclosporin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reports suggest cyclosporine levels may change with cyclophosphamide, and the combination increases immunosuppression and infection risk. Cyclophosphamide is a prodrug activated by CYP enzymes, and cyclosporine may alter its activation.
How serious is the interaction between Cyclophosphamide and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels, blood counts and renal function. Watch for infection.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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